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Table 2 Studies assessing the effect of diuretics on AKI and mortality

From: Fluid overload in the ICU: evaluation and management

Study

Number

Comparison

Effect on AKI

Effect on mortality

Mehta et al. [37]

552

Diuretics versus no diuretics

Increased risk of death or non-recovery of renal function

OR 1.68 for death with diuretic use

Uchino et al. [38]

1743

Diuretics versus no diuretics

N/A

No difference

Cantarovich et al. [39]

338

Furosemide versus placebo

No difference on renal recovery were found

No difference

Grams et al. [40]

FACTT trial

306

Fluid conservative

(Furosemide dose of 80 mg) versus fluid liberal

(Furosemide dose of 23 mg)

No difference in peak sCr

No difference

  1. FACTT fluid and catheter treatment trial, sCr serum creatinine, NA non-assessed, OR odds ratio