Table 3 Performance on the cognitive tests at follow up based on kidney function at baseline
From: Processing speed is affected by early impairment in kidney function in the general elder population
Cognitive test | Cognitive domain | Mean result baseline | Mean result 6 year follow up | Mean change in test result from baseline to 6 year follow up | Mean difference in test result change between baseline and follow up (95 % CI) p–value | |||
|---|---|---|---|---|---|---|---|---|
Participants with eGFR < 60 mL/min/1,73 m2 from baseline to follow up (n) | Participants with eGFR ≥ 60 mL/min/1,73 m2 from baseline to follow up (n) | Participants with eGFR < 60 mL/min/1,73 m2 from baseline to follow up (n) | Participants with eGFR ≥ 60 mL/min/1,73 m2 from baseline to follow up (n) | Participants with eGFR < 60 mL/min/1,73 m2 from baseline to follow up (n) | Participants with eGFR ≥ 60 mL/min/1,73 m2 from baseline to follow up (n) | |||
MMSE | Global | 26.79 (192) | 27.83 (708) | 25.66 (184) | 27.43 (701) | –1.13 | –0.40 | –0.11 (–0.61, 0.38) 0.66 |
Digit span forwards | Learning and memory | 5.62 (194) | 5.80 (708) | 5.27 (195) | 5.62 (708) | –0.35 | –0.18 | –0.04 (–0.28, 0.20) 0.75 |
Free recall | Learning and memory | 6.55 (190) | 7.64 (699) | 5.67 (193) | 7.28 (707) | –0.88 | –0.36 | 0.13 (–0.37, 0.63) 0.62 |
Recognition | Learning and memory | 11.73 (188) | 12.43 (695) | 10.82 (193) | 12.15 (703) | –0.91 | –0.28 | –0.09 (–0.79, 0.61) 0.81 |
Word fluency | Language | 11.38 (196) | 13.56 (706) | 10.87 (193) | 13.42 (705) | –0.51 | –0.14 | 0.05 (–0.68, 0.78) 0.89 |
Digit cancellation | Complex attention | 15.82 (189) | 18.68 (704) | 15.06 (170) | 18.82 (698) | –0.76 | 0.14 | –0.30 (–0.96, 0.35) 0.36 |
Pattern comparison | Complex attention | 23.61 (189) | 30.45 (703) | 21.46 (170) | 30.03 (697) | –2.15 | –0.42 | –1.18 (–2.26, –0.09) 0.03 |
TMT Aa | Complex attention | 16.53 s (183) | 12.62 s (682) | 18.79 s (165) | 12.02 s (674) | 2.26 s | –0.60 s | 1.23 (–0.17, 2.62) 0.08 |
TMT Ba | Executive function | 36.33 s (141) | 25.37 s (628) | 47.66 s (128) | 26.23 s (621) | 11.33 s | 0.86 s | 1.19 (–3.90, 6.28) 0.65 |
Digit span backwards | Executive function | 4.02 (194) | 4.38 (707) | 3.82 (194) | 4.26 (708) | –0.20 | –0.12 | –0.04 (–0.28, 0.21) 0.78 |
Mental rotationsb | Perceptual motor | 0.57 (181) | 0.65 (696) | 0.56 (175) | 0.61 (702) | –0.01 | –0.04 | 0.02 (–0.03, 0.06) 0.52 |
Confidence judgementc | Meta–memory | 0.09 (191) | 0.11 (697) | 0.09 (194) | 0.10 (708) | 0.00 | –0.01 | 0.01 (–0.02, 0.03) 0.62 |