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Table 1 Characteristics of 503 Hemodialysis Patients by Levels of NTproBNP and cTnI

From: Association of NTproBNP and cTnI with outpatient sudden cardiac death in hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) study

  

NTproBNP (pg/mL) Categories

Troponin I (ng/mL) Categories

      

Below Detection Limit

Detectable

 

Characteristic

Overall

Low

Mid

High

p

Low

Mid

High

p

Range, minimum to maximum

 

59–1710

1728–7269

7350–273502

-

<0.015

0.015–0.039

0.04–3.09

-

N (%)

503 (100)

168 (33.4)

168 (33.4)

167 (33.2)

-

336 (66.8)

85 (16.9)

82 (16.3)

-

TNI, median (25th-75th percentiles) ng/mL

<0.015(<0.015–0.023)

<0.015

<0.015(<0.015–0.020)

0.021(<0.015–0.049)

-

<0.015

0.023(0.020–0.029)

0.085(0.052–0.162)

-

NTproBNP, median (25th-75th percentiles) pg/mL

3138(1233–9835)

822.5(489.5–1238)

3145.5(2364–4622)

14735(9835–24240)

-

2205(945–5670.5)

7166(2326–16018)

10242(4187–23407)

-

Demographics

         

Age, years

57.8 (14.7)

52.7 (13.8)

59.8 (15.2)

60.9 (13.6)

<0.001

56.1 (15.4)

60.3 (13.1)

62.1 (11.9)

<0.001

White

321 (63.8)

99 (58.9)

101 (60.1)

121 (72.5)

0.017

225 (67.0)

50 (58.8)

46 (56.1)

0.107

Male

273 (54.3)

91 (54.2)

88 (52.4)

94 (56.3)

0.773

164 (48.8)

55 (64.7)

54 (65.9)

0.002

Clinical Characteristics

         

Body Mass Index, Kg/m2

27.4 (7.1)

28.2 (7.8)

28.1 (7.5)

25.8 (5.6)

0.002

27.6 (7.3)

27.0 (6.7)

26.9 (6.9)

0.297

Cause of End Stage Renal Disease

         

Diabetes mellitus

248 (49.3)

77 (45.8)

82 (48.8)

89 (53.3)

0.389

157 (46.7)

46 (54.1)

45 (54.9)

0.259

Hypertension

86 (17.1)

21 (12.5)

27 (16.1)

38 (22.8)

0.041

50 (14.9)

18 (21.2)

18 (22.0)

0.172

Glomerulonephritis

74 (14.7)

36 (21.4)

25 (14.9)

13 (7.8)

0.002

58 (17.3)

9 (10.6)

7 (8.5)

0.068

Other

95 (18.9)

34 (20.2)

34 (20.2)

27 (16.2)

0.547

71 (21.1)

12 (14.1)

12 (14.6)

0.189

ICED = 3

147 (29.3)

41 (24.4)

46 (27.5)

60 (35.9)

0.057

97 (29.0)

20 (23.5)

30 (36.6)

0.175

Diabetes

287 (57.2)

85 (50.6)

95 (56.9)

107 (64.1)

0.045

180 (53.7)

54 (63.5)

53 (64.6)

0.087

Cardiovascular Disease

279 (55.6)

64 (38.1)

102 (61.1)

113 (67.7)

<0.001

165 (49.3)

58 (68.2)

56 (68.3)

<0.001

Congestive Heart Failure

247 (49.2)

58 (34.5)

80 (47.9)

109 (65.3)

<0.001

146 (43.6)

54 (63.5)

47 (57.3)

0.001

Coronary Heart Disease

209 (41.6)

42 (25)

77 (46.1)

90 (53.9)

<0.001

114 (34.0)

47 (55.3)

48 (58.5)

<0.001

Myocardial Infarction

120 (23.9)

20 (11.9)

51 (30.5)

49 (29.3)

<0.001

68 (20.3)

23 (27.1)

29 (35.4)

0.012

Left Ventricular Hypertrophy

137 (27.3)

43 (25.6)

41 (24.6)

53 (31.7)

0.281

74 (22.1)

29 (34.1)

34 (41.5)

0.001

Time Since Start of Dialysis, Months

5.0 (1.6)

5.0 (1.5)

4.7 (1.5)

5.2 (1.6)

0.189

4.9 (1.5)

5.3 (1.5)

5.1 (1.7)

0.168

Laboratory Tests

         

Blood Urea Nitrogen, mg/dL

57.8 (15.1)

57.6 (15.3)

58.3 (15.4)

57.6 (14.8)

0.998

57.3 (15.5)

59.3 (14.9)

58.4 (14.1)

0.482

Kt/VUREA

1.3 (0.302)

1.3 (0.324)

1.3 (0.278)

1.3 (0.303)

0.250

1.3 (0.316)

1.3 (0.255)

1.3 (0.292)

0.788

Creatinine, mg/dL

8.0 (2.9)

8.2 (2.8)

8.2 (3.2)

7.6 (2.5)

0.081

8.1 (2.9)

7.9 (2.7)

7.6 (2.8)

0.311

Potassium, mEq/L

4.7 (0.665)

4.6 (0.584)

4.7 (0.712)

4.7 (0.680)

0.036

4.7 (0.642)

4.7 (0.689)

4.7 (0.733)

0.665

Glucose, mg/dL

167.0 (103.0)

162.3 (79.0)

164.0 (82.7)

174.8 (137.2)

0.780

159.9 (83.4)

178.4 (120.0)

183.9 (145.3)

0.222

Bicarbonate, mEq/L

20.4 (2.9)

20.7 (2.7)

20.0 (3.0)

20.5 (2.9)

0.510

20.4 (2.9)

20.7 (2.5)

20.2 (3.4)

0.919

Hemoglobin, g/dL

11.0 (1.3)

11.2 (1.5)

10.9 (1.3)

10.8 (1.3)

0.003

11.0 (1.4)

11.2 (1.2)

10.8 (1.4)

0.686

Corrected Calcium, mg/dL

9.8 (0.883)

9.7 (0.854)

9.8 (0.954)

9.8 (0.839)

0.471

9.8 (0.881)

9.8 (0.918)

9.6 (0.844)

0.050

Phosphate, mg/dL

5.5 (1.7)

5.5 (1.6)

5.5 (1.8)

5.6 (1.6)

0.348

5.5 (1.7)

5.8 (1.6)

5.6 (1.9)

0.283

Albumin, g/dL

3.5 (0.549)

3.7 (0.503)

3.5 (0.568)

3.4 (0.547)

<0.001

3.5 (0.533)

3.5 (0.621)

3.5 (0.538)

0.559

CRP, mg/L (median, 25th – 75th percentiles)

0.445(0.203–1.219)

0.382(0.158–0.779)

0.486(0.224–1.317)

0.51

(0.217–1.496)

0.007

0.441(0.195–1.229)

0.431(0.148–1.04)

0.489(0.222–1.155)

0.980

IL-6, pg/mL (median, 25th – 75th percentiles)

4.8 (2.8–8.2)

3.8 (2.3–5.6)

5.2 (2.7–8.9)

6.2 (3.6–11.5)

<0.001

4.3 (2.6–7.4)

5.3 (3.4–9.0)

6.1 (3.6–11.7)

0.008

P-Selectin, ng/ml (median, 25th – 75th percentiles)

97.2

(75.6–126.0)

93.4

(74.0–125.9)

96(73.9–124.1)

98.7

(79.4–130.2)

0.526

96.3

(76.2–127.7)

94.7(72.2–117.0)

105.5(78.2–124.5)

0.627

Antihypertensive Medications, %

         

β-blockers

123 (24.5)

36 (21.4)

40 (23.8)

47 (28.1)

0.350

84 (25.0)

21 (24.7)

18 (22.0)

0.846

ACE-inhibitors

147 (29.2)

40 (23.8)

51 (30.4)

56 (33.5)

0.136

87 (25.9)

29 (34.1)

31 (37.8)

0.058

Calcium Channel Blockers

309 (61.4)

105 (62.5)

109 (64.9)

95 (56.9)

0.304

205 (61.0)

60 (70.6)

44 (53.7)

0.077

  1. Abbreviations: Troponin I, TNI; Hazard Ratio, HR; N-terminal pro-brain natriuretic peptide, NTproBNP
  2. For TNI, low category refers those patients with TNI below the limit of detection (<0.015 ng/mL; n = 336). Remaining patients are divided into two groups at the median. Mid category refers to the group below median TNI for those with detectable values (<0.040 ng/mL; n = 85) and high category refers to those with values at or above median (≥0.040 ng/mL; n = 82)
  3. For NTproBNP, low, mid and high category refers to the lowest, middle and highest tertiles of NTproBNP
  4. P-values represent p-trend by linear regression for continuous variables and chi-square p-values for categorical variables
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BMC Nephrology

ISSN: 1471-2369

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