Association of NTproBNP and cTnI with outpatient sudden cardiac death in hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) study

Table 3 Risk Prediction for Sudden Cardiac Death with NTproBNP and cTnI in 503 Hemodialysis Patients of the CHOICE Study

	Model 4^a	+NTproBNP	+cTnI	+NTproBNP and cTnI
3-Year Risk
C-Statistic	0.790 (0.728 to 0.851)	0.810 (0.757 to 0.864)	0.791 (0.732 to 0.849)	0.810 (0.756 to 0.864)
Change in C-Statistic^b	Ref	0.020 (−0.016 to 0.057)	0.001 (−0.019 to 0.021)	0.020 (−0.017 to 0.057)
NRI, Binary	Ref	0.125 (0.032 to 0.219)	0.033 (−0.021 to 0.088)	0.133 (0.039 to 0.227)
NRI, Continuous	Ref	0.262 (−0.048 to 0.572)	0.125 (−0.186 to 0.436)	0.212 (−0.098 to 0.522)
5-Year Risk
C-Statistic	0.773 (0.723 to 0.823)	0.797 (0.751 to 0.843)	0.778 (0.730 to 0.827)	0.797 (0.751 to 0.843)
Change in C-Statistic	Ref	0.024 (−0.004 to 0.053)	0.006 (−0.009 to 0.021)	0.024 (−0.005 to 0.053)
NRI, Binary	Ref	0.063 (−0.028 to 0.154)	0.001 (−0.065 to 0.067)	0.072 (−0.020 to 0.164)
NRI, Continuous	Ref	0.270 (0.046 to 0.495)	0.018 (−0.207 to 0.243)	0.356 (0.132 to 0.581)

Abbreviations: SCD sudden cardiac death; NTproBNP, and N-terminal prohormone of brain natriuretic peptide; cTnI cardiac troponin I; CVD cardiovascular disease; DM diabetes mellitus; C-statistic, concordance statistic, NRI net reclassification index
^a Model 4: Adjusted for demographics (age, sex and race), clinical factors [smoking status (ever versus never), Index of Coexistent Disease (ICED) score, diabetes, cardiovascular disease, congestive heart failure, body mass index and systolic blood pressure], left ventricular hypertrophy, β-blocker use and laboratory tests including hemoglobin, serum albumin, serum potassium, serum bicarbonate, serum corrected calcium and serum phosphate
^b Change in C-statistic by adding biomarker to the variables in Model 4

ISSN: 1471-2369