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Table 5 Statistical usefullness of serum copeptin levels as a marker of a FMD, PWV, eGFR, or CIMT above or below the variable median for the cohort at baseline

From: Vasopressin-related copeptin is a novel predictor of early endothelial dysfunction in patients with adult polycystic kidney disease

Variable

Area under curve

Diagnostic statistics

AUC

p

Co-peptin cut-off used (from ROC)

SEN (%)

SPE (%)

PPV(%)

NPV(%)

FMD (> or ≤7.1%)

0.75(0.68–0.80)

<0.001

0.59 ng/mL

88.0(79.6–93.6)

57.4(47.5–66.9)

63.8(54.8–72.1)

84.9(74.6–92.2)

PWV (> or ≤7.8 m/sec)

0.58(0.50–0.65)

0.064

0.76 ng/mL

51.1(40.4–61.7)

71.3(61.8–79.6)

60.8(48.5–71.2)

63.1(53.9–71.7)

eGFR(> or ≤59 mL/min/1.73 m2)

0.61(0.54–0.68)

0.008

0.81 ng/mL

43.5(33.2–55.2)

60.2(50.3–60.9)

52.2(41.4–62.9)

59.1(49.3–68.4)

cIMT (> or ≤0.8 mm)

0.86(0.80–0.90)

<0.001

0.58 ng/mL

79.4(69.6–87.1)

88.9(81.4–94.1)

85.9(76.6–92.5)

83.5(75.4–89.7)

  1. AUC Area under curve, SEN Specificity, SPE Specificity, PPV Positive predictive value, NPV Negative predictive value