Table 1 Biochemical characteristics of proband and his sister carrying SCNN1G mutation before and after amiloride treatment. PAC – plasma aldosterone concentration, PRA – plasma renin activity
Patient | Sex | Age | BP, mm Hg average (maximum) | PAC, pg/mL | Normal range of PAC, pg/mL | PRA, ng/mL/h | Normal range of PRA, ng/mL/h | K+, mmol/L | Normal range of K+, mmol/L |
|---|---|---|---|---|---|---|---|---|---|
Proband before amiloride treatment | M | 15 | 149/95 (159/109) | 88,968 | 10–160 pg/ml | 0,1 | 1,2-2,4 | 3,4 | 3,7-5,12 |
Proband after amiloride treatment | 16 | 140/90 (160/110) | 15 | 2,13 | 4,8 | ||||
Sister of proband before amiloride treatment | F | 14 | 120/80 (160/100) | 9,7 | 1,01 | 4,0 | |||
Sister of proband after amiloride treatment | 15 | 115/69 (141/98) | 10 | 2 | 4,7 |