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Table 2 Urinary excretion of proteins from epithelial sodium channels, aquaporin-2 channels, Neutrophil gelatinase-associated lipocalin and kidney injury molecule-1

From: Effect of 0.9% NaCl compared to plasma-lyte on biomarkers of kidney injury, sodium excretion and tubular transport proteins in patients undergoing primary uncemented hip replacement – a randomized trial

Period

Baseline

(1 day before surgery)

Follow-up

(14 days after surgery)

U-Aqua (ng/mmol crea)

 PlasmaLyte

194.3 [165.7;244.4]

225.7 [175.9;258.4]

 Sodiumchloride

196.9 [169.3;245.7]

220.0 [191.5;294.8]*

U-ENaC ((ng/mmol crea)

 PlasmaLyte

116.8 ± 46.2

145.1 ± 46.9*

 Sodiumchloride

120.6 ± 42.4

139.1 ± 42.2

U-NCC (ng/mmol crea)

 PlasmaLyte

105.1 ± 26.8

146.2 ± 46.4*

 Sodiumchloride

94.9 ± 33.4

133.0 ± 53.3*

U-NKCC (ng/mmol crea)

 PlasmaLyte

154.2 ± 38.7

171.6 ± 57.4

 Sodiumchloride

142.9 ± 33.5

155.5 ± 46.3

U-NGAL (ng/mmol crea)

 PlasmaLyte

1446 [1238;3161]

1840[1303;2679]

 Sodiumchloride

1577[866;3403]

1658[961;2494]

U-KIM (ng/mmol crea)

 PlasmaLyte

109.4 ± 61.6†

134.5 ± 68.7*†

 Sodiumchloride

73.7 ± 47.3

93.8 ± 59.9*

U-NGAL (ng/mL)

 PlasmaLyte

9.5 [8.0;13.5]

11.0 [7.3;13.0]

 Sodiumchloride

10.5 [5.0;13.0]

9.5 [7.5;15.5]

U-KIM (ng/mL)

 PlasmaLyte

0.54 [0.38;0.68]

0.64 [0.44;0.93]*

 Sodiumchloride

0.37 [0.19;0.57]

0.41 [0.24;0.80]

  1. Neutrophil gelatinase-associated lipocalin (u-NGAL/creatinine) and kidney injury molecule-1 (u-KIM-1/ creatinine), γ-fraction of the epithelial sodium channel (u-ENaCγ/creatinine), aquaporin-2 (u-AQP-2/ creatinine). Values are shown as means ± SD in brackets or medians with 25 and 75 percentiles in brackets
  2. Statistics are performed with unpaired t-test or Mann-Whitney test to test difference in response between treatments, † = p < 0.05. Paired t-test or Wilcoxon signed rank test was used to test statistical significant difference from baseline, * = p < 0.05
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BMC Nephrology

ISSN: 1471-2369

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