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Table 5 Urinary excretion of proteins from epithelial sodium channels, aquaporin-2 channels, Neutrophil gelatinase-associated lipocalin and kidney injury molecule-1

From: Effect of 0.9% NaCl compared to plasma-lyte on biomarkers of kidney injury, sodium excretion and tubular transport proteins in patients undergoing primary uncemented hip replacement – a randomized trial

Period

Admission

Surgery

Post-surgery

Discharge

P (GLM within)

U-NGAL (ug/mmol crea)

 PlasmaLyte

1.03 [0.63;2.33]

1.03[0.79;1.68]

1.28 [0.81;2.68]

7.08* [5.66;13.18]

0.376

 Sodiumchloride

0.78 [0.57;1.10]

0.88 [0.50;1.17]

1.01 [0.72;1.35]

7.97* [4.77;12.63]

 P (GLM between)

0.523

 

U-KIM (ng/mmol crea)

 PlasmaLyte

97.0 [50.1;183.4]

92.4 [68.18;152.7]

179.5* [109.1;244.2]

301.0*[176.5;427.1]

0.324

 Sodiumchloride

70.0 [37.9;117.7]

68.0 [45.9;134.6]

85.1* [67.7;167.8]

183.0* [125.5;313.2]

 P (GLM between)

0.116

 

U-NGAL (ng/mL)

 PlasmaLyte

7.5[4.0;21.3]

5.0[2.0;8.0]*

14.0[7.3;31.8]*

72.0[43.3;158.5]*

0.644

 Sodiumchloride

5.0[2.0;10.0]

3.5[2.0;6.0]

9.0[6.5;11.5]

142.0[66.3;196.3]*

 P (GLM between)

0.728

 

U-KIM (ng/mL)

 PlasmaLyte

1.10[0.16;1.34]

0.46[0.09;0.68]

1.37[0.97;2.91]*

3.71[1.97;6.62]*

0.627

 Sodiumchloride

0.41[0.12;0.86]

0.42[0.16;0.62]

0.75[0.43;1.61]*

2.48[1.12;4.91]*

 P (GLM between)

0.910

 

U-ENaC (ng/mmol crea)

 PlasmaLyte

107.7 ± 45.7

137.0 ± 47.2*

132.2 ± 28.8*

233.8 ± 84.0*

0.019

 Sodiumchloride

116.7 ± 52.0

195.3 ± 71.3*

141.5 ± 57.1

218.2 ± 52.8*

 P (GLM between)

0.222

 

U-Aqua (ng/mmol crea)

 PlasmaLyte

180.2 [155.1;227.4]

263.9 [216.3;360.0]*

340.5 [275.3;455.7]*

357.1 [252.9;589.4]*

0.693

  Sodiumchloride

192.6 [149.8;217.2]

334.9 [241.1;374.5]*

300.8 [229.4;393.9]*

416.9 [269.7;574.6]*

 P (GLM between)

0.972

 

U-NCC (ng/mmol crea)

 PlasmaLyte

123.4 [99.4;137.4]

254.5 [174.5;320.7]*

156.7 [135.6;197.2]*

217.1 [193.1;288.0]*

0.321

 Sodiumchloride

112.5 [77.5;156.8]

242.6 [201.3;271.0]*

191.4 [162.9;220.8]*

225.6 [185.6;283.2]*

 P (GLM between)

0.855

 

U-NKCC (ng/mmol crea)

 PlasmaLyte

171.7 ± 70.9

338.4 ± 156.7*

179.1 ± 49.1

203.5 ± 80.0

0.304

 Sodiumchloride

161.2 ± 58.2

283.9 ± 117.8*

186.3 ± 66.3

211.6 ± 106.4*

 P (GLM between)

0.566

 
  1. Neutrophil gelatinase-associated lipocalin (u-NGAL/creatinine) and kidney injury molecule-1 (u-KIM-1/ creatinine), γ-fraction of the epithelial sodium channel (u-ENaCγ/creatinine), aquaporin-2 (u-AQP-2/ creatinine). Values are shown as means ± SD or medians with 25 and 75 percentiles in brackets. Statistics are performed with a general linear model (GLM). Paired t-test or Wilcoxon signed rank test was used to test statistical significant difference from baseline with -in group, * = p < 0.05
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BMC Nephrology

ISSN: 1471-2369

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