Effect of 0.9% NaCl compared to plasma-lyte on biomarkers of kidney injury, sodium excretion and tubular transport proteins in patients undergoing primary uncemented hip replacement – a randomized trial

Table 6 GFR and tubular function

Period	Baseline	Surgery (0–4 h)	Post-surgery (4–24 h)	P-value (difference in response)
C_H2O (mL/minute)
PlasmaLyte	−0.85 ± 0.66	−0.77 ± 1.21	−1.08 ± 0.43*	0.725
Sodiumchloride	−0.80 ± 0.72	−0.83 ± 0.70	−1.17 ± 0.49	0.725
Creatinine clearance (mL/minute)
PlasmaLyte	124.3 ± 31.4	147.4 ± 46.3*	137.3 ± 39.9*	0.362
Sodiumchloride	116.6 ± 29.3	129.2 ± 31.4	137.2 ± 29.4*	0.362
FE_K (%)
PlasmaLyte	11.6 ± 4.3	20.9 ± 8.6*	12.0 ± 6.2	0.002
Sodiumchloride	12.8 ± 3.3	16.2 ± 4.7*	10.7 ± 3.8*	0.002
FE_Cl (%)
PlasmaLyte	1.04 ± 0.80	1.45 ± 1.23	0.63 ± 0.46*	0.806
Sodiumchloride	1.05 ± 0.42	1.53 ± 0.69*	0.92 ± 0.49	0.806

Free water clearance (CH2O), creatinine clearance, potassium (FEK) and Chloride (FECl). Values are shown as means ± SD or medians with 25 and 75 percentiles in brackets. Statistics are performed with a general linear model (GLM)
Paired t-test or Wilcoxon signed rank test was used to test statistical significant difference from baseline with -in group, * = p < 0.05

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