Variables | All patients (n = 562) | Death/graft loss (n = 94) | No event (n = 468) | P |
---|---|---|---|---|
Age at study entry (years) | 54.6 (44.5–66.9) | 62.5 (54.0–71.6) | 53.4 (43.0–64.2) | < 0.0001 |
Male, n (%) | 345 (61.4%) | 68 (72.3%) | 227 (59.2%) | 0.017 |
Primary kidney diseases, n (%) | 0.888 | |||
Glomerulonephritis | 228 (40.6%) | 38 (40.4%) | 190 (40.6%) | |
Tubulointerstitial disease | 54 (9.6) | 9 (9.6%) | 45 (9.6%) | |
Polycystic renal disease | 70 (12.5%) | 10 (10.6%) | 60 (12.8%) | |
Dysplasia and hypoplasia | 8 (1.4%) | 1 (1.1%) | 7 (1.5%) | |
Diabetic nephropathy | 18 (3.2%) | 3 (3.2%) | 15 (3.2%) | |
Hypertensive nephropathy | 16 (2.8%) | 2 (2.1%) | 14 (3.0%) | |
Other or unknown cause | 168 (29.9) | 31 (33.0%) | 137 (29.3%) | |
Time post-transplantation (years) | 5.89 (2.90–10.48) | 6.93 (3.65–12.23) | 5.69 (2.88–10.37) | 0.063 |
Time on dialysis (month) | 46.0 (19.0–75.0) | 50.0 (21.5–73.5) | 44.0 (19.0–76.0) | 0.503 |
Donor age (years) | 51.0 (40.0–61.0) | 54.0 (42.0–68.0) | 50.0 (39.0–59.0) | 0.013 |
Cold ischemia time (hours) | 8.51 (3.24–14.04) | 9.92 (6.42–18.16) | 8.18 (3.02–13.73) | 0.023 |
Hemoglobin (g/dl) | 12.71 ± 1.76 | 12.20 ± 1.78 | 12.81 ± 1.74 | 0.002 |
Serum albumin (g/dl) | 4.55 ± 0.35 | 4.46 ± 0.36 | 4.57 ± 0.35 | 0.04 |
Total cholesterol (mg/dl) | 217.0 (186.0–254.0) | 210.0 (171.5–247.3) | 218.0 (187.0–254.8) | 0.221 |
Serum creatinine (mg/dl) | 1.57 (1.26–2.06) | 2.23 (1.42–3.02) | 1.52 (1.24–1.94) | < 0.0001 |
eGFR (mL/min/1.73 m2) | 43.0 (31.0–58.0) | 30.0 (21.0–50.5) | 44.5 (34.0–58.0) | < 0.0001 |
Serum calcium (mmol/L) | 2.47 (2.37–2.59) | 2.42 (2.33–2.57) | 2.48 (2.39–2.59) | 0.014 |
Serum phosphorus (mmol/L) | 0.86 (0.71–1.02) | 0.99 (0.77–1.23) | 0.84 (0.69–0.98) | < 0.0001 |
Parathyroid hormone (pg/ml) | 79.18 (49.91–133.70) | 104.9 (58.76–206.3) | 76.34 (49.06–126.60) | 0.002 |
Intact FGF23 (pg/ml) | 30.94 (15.43–68.98) | 45.24 (18.63–159.0) | 29.04 (15.23–60.65) | 0.002 |
C terminal FGF23 (pg/ml) | 12.57 (6.38–27.38) | 24.59 (11.43–87.82) | 10.67 (5.99–22.73) | < 0.0001 |
Urinary protein excretion (mg/24 h) | 163.0 (99.0–306.5) | 265.5 (129.5–691.5) | 153.0 (96.0–274.0) | 0.0001 |