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Table 1 Baseline characteristics according to disease aetiology for all patients attending the AKCS clinic from 2011 to 2018

From: A validation study of the kidney failure risk equation in advanced chronic kidney disease according to disease aetiology with evaluation of discrimination, calibration and clinical utility

Variable

Whole cohort

Diabetic nephropathy

Hypertensive nephropathy

GN

ADPKD

Other diseases

Patient numbers

743

178

125

86

64

290

Age, years

68.5 (56.9–77.1)

66.1 (57.4–74.9)

76.3 (69.0–81.5)

62.6 (47.1–72.5)

54.3 (46.4–63.3)

71.2 (61.3–78.5)

Male, n (%)

462 (62)

118 (66)

83 (66)

55 (64)

38 (59)

165 (57)

Caucasian, n (%)

695 (94)

163 (92)

121 (97)

79 (92)

63 (98)

275 (95)

Hypertension, n (%)

723 (97)

176 (99)

125 (100)

85 (99)

61 (95)

276 (95)

Diabetes mellitus, n (%)

296 (40)

178 (100)

33 (26)

17 (20)

2 (3)

66 (23)

Laboratory values

aeGFR, ml/min/1.73m2

16 (13–18)

16 (13–19)

15 (13–18)

16 (12–18)

16 (13–18)

15 (13–18)

burine albumin:creatinine ratio, mg/g

409 (85–1356)

896 (245–2304)

172 (43–621)

1345 (496–2520)

130 (45–332)

362 (80–996)

cCalcium, mg/dL

9.32 (8.96–9.72)

9.36 (9.04–9.75)

9.20 (8.76–9.56)

9.28 (8.96–9.76)

9.32 (8.91–9.56)

9.40 (8.96–9.76)

cPhosphate, mg/dL

3.91 (3.41–4.53)

4.00 (3.44–4.62)

3.81 (3.32–4.50)

4.31 (3.60–4.86)

4.03 (3.57–4.35)

3.84 (3.32–4.37)

 Bicarbonate, mEq/L

21.8 (19.6–24.4)

22.4 (20.3–25.5)

21.6 (19.7–23.8)

20.8 (19.2–23.5)

22.2 (19.1–23.8)

21.7 (19.4–24.4)

dAlbumin, g/dL

4.2 (3.9–4.4)

4.0 (3.7–4.2)

4.2 (4.0–4.4)

4.0 (3.7–4.3)

4.4 (4.2–4.6)

4.2 (3.9–4.4)

KFRE scores

 4-variable 2-year score, %

24 (11–42)

31 (13–53)

15 (7–30)

39 (23–66)

19 (11–33)

22 (10–36)

 4-variable 5-year score, %

65 (36–88)

76 (43–95)

47 (24–75)

85 (63–98)

56 (36–79)

61 (33–83)

 8-variable 2-year score, %

20 (10–39)

23 (12–46)

15 (7–28)

31 (18–67)

18 (9–28)

19 (9–32)

 8-variable 5-year score, %

64 (37–89)

68 (45–94)

53 (27–77)

81 (59–99)

60 (34–78)

61 (35–82)

  1. Continuous data expressed as median (interquartile range) and categorical data as number (percentage)
  2. Abbreviations: AKCS Advanced kidney care service clinic), GN glomerulonephritis, ADPKD autosomal dominant polycystic kidney disease, eGFR estimated glomerular filtration rate, ESRD end-stage renal disease, KFRE Kidney Failure Risk Equation
  3. aeGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. burine albumin:creatinine ratios were acquired by converting urine protein:creatinine ratios using a validated formula [9]. cCalcium and phosphate were measured in mmol/L and converted to mg/dL by multiplying values by 4 and 3.1 respectively. dAlbumin was measured in g/L and converted to g/dL by dividing by 10