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Table 2 KPIs overall (n = 205) and by liver function (preserved liver function, n = 143; reduced liver function, n = 60). (To be placed after ‘Results’ subsection ‘Overall performance of eGFR equations’)

From: Impact of race-independent equations on estimating glomerular filtration rate for the assessment of kidney dysfunction in liver disease

KPI

Equation

Overall

Preserved Liver Function (PLF)

Reduced Liver Function (RLF)

Difference in KPI between RLF and PLF

Precision: IQRa

eGFRcr(ASR)

19 [12–22]*

12.5 [10.5–16.5]

29.25 [23–35.5]*

-16.75 [-23.5–-8.01]

eGFRcr(AS)

19 [12–22.97]*

13 [10.5–16]

31.5 [24–37.74]*

-18.5 [-25.25–-10.26]

eGFRcr-cys(ASR)

14 [12–17]

10 [9–12.5]

15.25 [10.25–21.24]

-5.25 [-10.75–0.75]

eGFRcr-cys(AS)

13 [10–15]

11 [9–14]

13.5 [9–21]

-2.5 [-10.25–2.5]

GFRNMR

14 [12–16]

14 [11–16]

14.5 [10–22.49]

-0.5 [-8.99–4]

Bias: median biasb

eGFRcr(ASR)

1 [-1–3]*

-3 [-5–-1]

13 [9–25]*

-16 [-28–-11]

eGFRcr(AS)

4 [2–7]*

1 [-2–2]*

16.5 [12–28.99]*

-15.5 [-28–-10.01]

eGFRcr-cys(ASR)

-6 [-8–-5]*

-7 [-10–-6]*

2 [-2.5–4.5]*

-9 [-13–-4.5]

eGFRcr-cys(AS)

-4 [-6–-3]*

-6 [-7–-4]*

2 [0–5]*

-8 [-11–-5]

GFRNMR

-1 [-3–1]

-2 [-4–0]

1 [-3.5–2.5]

-3 [-5–2]

Accuracy: P10c

eGFRcr(ASR)

35.61 [29.27–41.95]

41.96 [33.57–49.65]

21.67 [11.67–31.67]

20.29 [6.63–32.55]

eGFRcr(AS)

38.54 [31.22–44.88]

46.15 [37.76–53.85]

21.67 [11.67–31.67]

24.49 [10.73–37.28]

eGFRcr-cys(ASR)

31.22 [24.88–37.07]

30.77 [23.08–38.46]

31.67 [20–43.33]

-0.9 [-15.52–13.29]

eGFRcr-cys(AS)

35.12 [28.29–41.45]

35.66 [27.97–43.36]

33.33 [21.67–45]

2.33 [-12.02–16.09]

GFRNMR

41.95 [35.12–48.29]

42.66 [34.27–51.05]

41.67 [30–55]

0.99 [-13.74–15.35]

Accuracy:

P30c

eGFRcr(ASR)

75.12 [69.28–81.46]*

88.81 [83.22–93.71]

45 [33.33–56.67]*

43.81 [30.48–57.04]

eGFRcr(AS)

74.15 [68.29–80.49]*

87.41 [82.52–92.31]

45 [33.33–56.67]*

42.41 [29.35–55.64]

eGFRcr-cys(ASR)

85.85 [81.46–90.72]

88.81 [83.22–93.71]

78.33 [66.67–88.33]

10.48 [-0.64–22.57]

eGFRcr-cys(AS)

85.85 [80.99–90.24]

88.81 [83.22–93.71]

78.33 [66.67–88.33]

10.48 [-0.48–22.58]

GFRNMR

83.41 [78.54–88.78]

87.41 [82.52–92.99]

73.33 [61.67–85]

14.08 [1.71–26.61]

  1. Abbreviations: IQR interquartile range, KPI key performance indicator, PLF preserved Liver Function; RLF Reduced Liver Function
  2. aPrecision defined as the interquartile range (IQR) of the difference to mGFR (ml/min/1.73 m2); bBias defined as the median difference to mGFR (ml/min/1.73 m2); cP10 and P30 accuracy defined as the percentage of samples within an error tolerance to mGFR of 10% (P10) or 30% (P30) (%). Numbers in brackets show the bootstrapped 95% confidence intervals (n = 1000). Bold marked values show the best value for the given KPI over all five equations in the given subgroup. Symbol * indicates statistical significance (any p‐values < 0.05) in the pairwise tests against GFRNMR for each KPI. The last column shows the difference between reduced and preserved liver function in the given KPI for each equation as a measure of disparity