Performance of synacthen test in chronic hemodialysis patients

BMC Nephrology

Table 2 Equivalence test results for measured cortisol concentration (nmol/l) on log-scale shown in four different Syancthen dose and time settings. Estimates were fitted in a multivariable linear mixed model with random intercepts per subject accounting for multiple measurement at different time points after Synacthen. It was further adjusted for patient and HD variables: cortisol concentration shortly before Synacthen administration, albumin at HD start on study day 1, glucose measured after Synacthen, daytime of HD, test sequence and study day

Synacthen dose	Time after Synacthen administration (min)	Time of Synacthen administration	Mean (SE) of cortisol concentration on log-scale	Difference in means of cortisol concentration on log-scale pre- vs. during HD [90% CI]
Low	30	pre-HD	6.654 (0.0375)	0.024 [-0.017, 0.066]
	30	during HD	6.630 (0.0373)	0.024 [-0.017, 0.066]
	60	pre-HD	6.474 (0.0373)	0.089 [0.048, 0.130]
	60	during HD	6.385 (0.0373)	0.089 [0.048, 0.130]
Standard	30	pre-HD	6.692 (0.0374)	0.034 [-0.007, 0.075]
	30	during HD	6.658 (0.0373)	0.034 [-0.007, 0.075]
	60	pre-HD	6.838 (0.0374)	0.043 [0.001, 0.084]
	60	during HD	6.796 (0.0374)	0.043 [0.001, 0.084]

Abbreviations: CI – confidence interval; HD – hemodialysis; SE – standard error. Means and differences of means of cortisol concentration (nmol/L) on log-scale in each Synacthen dose measured at 30 and 60 min after Synacthen. All 90% confidence intervals are entirely in equivalence region of (-0.22, 0.22). Equivalence of cortisol concentration pre- and during HD at 30 and 60 min after Synacthen was thus proven in all four scenarios

ISSN: 1471-2369