Fig. 5
From: Diagnosing Fabry nephropathy: the challenge of multiple kidney disease
Summary of elements that may suggest a diagnosis of Fabry nephropathy in patients with kidney dysfunction and albuminuria. EM is the most important single examination leading to FD nephropathy diagnosis, beyond specific genetic and functional tests. Age of onset/severity and disease course may vary depending on gender, (better in heterozygote females than in males), residual α-gla activity and specific mutation on GLA gene. Abbreviations: LM. Light microscopy; EM, electron microscopy; IFG, immunofluorescence. *Many clinical signs and laboratory and histological features may be common to other lysosome storage disorders or drug-induced phospholipidosis