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Table 7 Sensitivity analysis results

From: Impact of compliance to oral cysteamine treatment on the costs of Kidney failure in patients with nephropathic cystinosis in the United Kingdom

Scenario

Unit

Base case

Scenario

Result

Impact on results

Base case

-

-

-

-£25,460

-

OS HR (-2.5%)

-

0.96

0.94

-£7,047

£18,413

Mean age-at-KF (30)

Years

23.00

30.00

-£43,221

-£17,761

OS HR (+ 2.5%)

-

0.96

0.99

-£41,989

-£16,529

Mean age-at-KF (18)

Years

19.50

18.00

-£9,551

£15,910

Annual compliance score: 3

ACS

2.25

3.00

-£37,950

-£12,490

Number of transplants

-

2.00

3.00

-£18,261

£7,200

Applying a HR of 1 to SKF curve in Poor Compliance

-

1.01

1.00

-£20,724

£4,736

Graft failure time (17.50 years)

Years

20.62

17.50

-£29,114

-£3,653

Waiting list for transplant time (36 months)

Months

9.04

36.00

-£28,856

-£3,396

Discount rate (1.5%)

%

0.04

0.02

-£22,188

£3,272

Graft failure time (22.50 years)

Years

20.62

22.50

-£23,500

£1,961

Waiting list for transplant time (0 months)

Months

9.04

0.00

-£24,581

£879

  1. KF: Kidney Failure, HR: Hazard ratio, TTD: Time-to-death