Table 2 Inclusion and exclusion criteria

Population

Any human kidney transplant recipients

Animal studies, studies involving other solid organ transplants or bone marrow transplants

Due to studies aims and the varying biological processes and pathology in both animals and other human transplant populations

Language

Studies from all languages will be included

N/A

Studies written in languages other than research teams’ will be translated using available services at the research centre

Time period

From inception to present

N/A

Anticipation that most studies will be contemporary given nature of technology

Study location

All locations included

N/A

Worldwide problem not restricted to a geographical region

Study Focus

All studies which use any proteomic analysis technique to investigate kidney transplant graft outcome or pathology known to affect kidney transplant function; non exhaustive list rejection, viral infection, medication related injury, delayed graft function, acute kidney injury, prolonged ischaemia

Studies which do not specifically investigate prognostic and/or or diagnostic power of proteomics in kidney transplant grafts

Based on aim of the review

Sample Type

Any human biological sample including renal biopsy tissue, serum and urine from either donor or recipient, samples used during preparation of kidney transplant

N/A

In keeping with methodology broad range of samples relevant to kidney transplant will be included

Proteomic techniques

All studies profiling for differential protein expression changes etc. ELISA and western blot data (targeted towards specific candidates), and antibody-based multiplex immunoassays or mass spectrometry-based proteomics (discovery/untargeted proteomics)

N/A

Including targeted and untargeted proteomic techniques allows the review to capture full range of studies in kidney transplant recipients

Types of Sources

Articles, reviews, books, book chapters, text and opinion papers, web resources—grey literature

N/A

In keeping with scoping review methodology studies of all designs can be included the review including non-published material