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Table 2 Literature review

From: Atypical anti-glomerular basement membrane disease with membranous hyperplasia: diagnostic challenges and treatment variability

Case

(age/sex)

Pathology

Immunofluorescence

IgG

anti-GBM antibodies

Electron microcopy

31/M

Proliferative basement membranes, focal crescents, and mesangial proliferation.

IgG (+); IgA (+); IgM (+); C3 (-); C1q (-); Fib (-); ALB (-); kappa (+); and lambda (+).

linear deposition

Negative

No electron-dense deposits and presence of foot process fusion.

57/F [20]

Mesangial proliferation, and focal crescents.

IgG (+); IgA (+); IgM (-); C3 (+); C1q (-); kappa (+); and lambda (+).

linear deposition

Negative

No electron-dense deposits and extensive FPE.

53/M [21]

Proliferative basement membranes, focal crescents, and segmental nodular glomerulosclerosis

IgG1 (+); IgG4 (+).

linear deposition

Negative

Fibrillar deposition.

74/M [22]

Mesangial proliferation, no crescents, and thinning basement membranes

IgG1 (+);IgG4 (+);IgG2 (+); kappa (+); and lambda (+).

linear deposition

Negative

Accumulation of flocculent debris.

43/F [23]

Focal crescents and endocapillary hypercellularity

IgG (+); IgA (-); IgM (-); C3 (-); C4 (-); C1q (-); IgG1 (+);IgG4 (+); IgG2 (-);IgG3 (-); kappa (+); and lambda (+).

linear deposition

Negative

Some FPE

13/F [24]

Mesangial proliferation, focal crescents, some globally or segmentally sclerosed glomeruli

IgG (+); IgA (+); IgM (-); C3 (+);C1q (-); IgG1 (+);IgG4 (+);kappa (+); and lambda (+).

linear deposition

Negative

NA

4/F [25]

Subtle segmental scars, segmental endocapillary hypercellularity, and cellular crescent

IgG (+);IgA (-); IgM (-); C3 (-); C1q (-).

linear deposition

Negative

No electron-dense deposits

30/M [26]

Normal

IgG (+);C3 (+);kappa (+); and lambda (+).

linear deposition

Negative

NA

58/M [27]

Focal crescents and proliferative, and sclerosing glomerulonephritis

IgG (+); IgA (+); kappa (+); and lambda (+).

linear deposition

Negative

NA

79/M [28]

NA

IgG (+); IgA (+); C3 (+); and lambda (+); fibrinogen (+).

linear deposition

Negative

NA

48/F [11]

Some globally sclerotic glomeruli, cellular and fibric crescents, Bowman’s capsules and segmental sclerotic glomeruli, tubular atrophy accompanied by interstitial fibrosis, interstitial infiltration of lymphocytes, monocytes, and plasmocytes

IgG (+)

linear deposition

Negative

No electron-dense deposits and presence of foot process fusion.

37/M [29]

diffuse proliferation in the glomeruli, with increased mesangial proliferation; crescents

IgG (+);C3 (+).

linear deposition

Negative

No electron-dense deposits.

64/M [30]

Necrotizing glomerulonephritis, cellular crescent, and diffuse segmental endocapillary proliferation.

IgG1-κ (+).

linear deposition

Negative

NA

69/M [31]

Mesangial proliferation, diffuse endocapillary hypercellularity, mesangiolysis, and extracapillary proliferation

IgG (+); IgG1 (+); IgG2 (+);IgG3 (-); IgG4 (-);

linear deposition

Negative

No electron-dense deposits, diffuse foot process effacement and subendothelial space widening

70/M [32]

Cellular crescents and necrotic lesions

IgG (+);IgM (-); C3 (-);kappa (+); and lambda (+); fibrinogen (+).

linear deposition

Negative

Proliferative basement membranes

46/F [12]

Cellular crescents and fibrinoid necrosis.

IgG (+); IgG1 (+); IgG2 (+);IgG3 (-); IgG4 (+).

linear deposition

Negative

Normal

53/F [33]

Interstitial fibrosis, tubular atrophy, moderate arteriosclerosis, and moderate arteriolar hyalinosis of moderate chronicity

IgG1-kappa (+); IgG1 (+); IgG2 (+);IgG3 (-); IgG4 (+).

linear deposition

Negative

No electron-dense deposits and extensive FPE

24/M [34]

Cellular crescents and mesangial proliferation,

IgG (+); IgA (+); IgM (-); C3 (-); C1q (-);IgG2 (+); IgG4 (+).

linear deposition

Negative

No electron-dense deposits

33/M [35]

Mesangial proliferation, focal interstitial fibrosis, and tubular atrophy

IgG (+);C3 (+); C4d (-).

linear deposition

Negative

NA

37/M [36]

Cellular crescents

IgG (-); IgA (+).

linear IgA deposition

Negative

NA

  1. +: positive; -: negative. FPE: podocyte foot process effacement. NA: not available