Skip to main content

Table 2 Histologic characteristics of the study cohort

From: Histological reappraisal of IgA nephropathy: the role of glomerular pattern of injury and mesangial complement deposition

Variable

Value

Global glomerulosclerosis (% of glomeruli)

17.6% (0–35)

LM pattern of glomerular injury (% of pts)

 

• Normal glomeruli

15.4%

• Mesangioproliferative glomerulonephritis

37.4%

• Proliferative/necrotizing glomerulonephritis

21.5%

• Crescentic glomerulonephritis

3.3%

• Sclerosing glomerulonephritis

22.4%

Oxford Classification (% of patients)

 

Mesangial hypercellularity (M1)

74.8%

Endocapillary hypercellularity (E1)

24.3%

Segmental sclerosis (S1)

58.4%

IFTA (T)

 

• T0 (≤ 25%)

56.5%

• T1 (26–50%)

27.6%

• T2 (> 50%)

15.9%

Crescents (C)

 

• C0

79.9%

• C1

14%

• C2

6.1%

C3 staining on IF

 

• Absent

8.3%

• Mild-Moderate

30.6%

• Intense

61.1%

IgA staining on IF

 

• Alone

21.8%

• IgA + IgG co-deposition

39.1%

• IgA + IgM co-deposition

39.1%

  1. Abbreviations: pts, patients; LM, light microscopy, M, mesangial hypercellularity; E, endocapillary hypercellularity; S, segmental sclerosis; IFTA, tubular atrophy and interstitial fibrosis; C, crescents; IF, immunofluorescence