Table 4 Univariate and multivariate cox proportional hazards regression analysis regarding predictive factors of renal outcome

Univariate analysis

Age (for 1 y)

1.003 (0.98–1.02)

0.76

1.01 (0.99–1.03)

0.33

Sex (male vs. female)

1.02 (0.56–1.84)

0.94

1.07 (0.62–1.86)

0.79

MAP (for 1 mmHg)

1.02 (1.009–1.04)

0.003

1.02 (1.01–1.04)

0.001

eGFR (for 1 ml/min/1.73m2)

0.91 (0.89–0.93)

< 0.001

0.93 (0.91–0.95)

< 0.001

Proteinuria (for 1 g/day)

1.16 (1.06–1.26)

0.001

1.14 (1.06–1.24)

0.001

Oxford Classification

• M1 vs. M0

1.48 (0.69–3.14)

0.31

1.36 (0.69–2.68)

0.37

• E1 vs. E0

1.34 (0.75–2.38)

0.32

1.15 (0.66-2)

0.6

• S1 vs. S0

1.18 (0.67–2.06)

0.55

1.31 (0.78–2.2)

0.31

• T1 vs. T0

2.82 (1.42–5.62)

0.003

2.97 (1.59–5.55)

0.001

• T2 vs. T0

8.38 (4.27–16.4)

< 0.001

7.85 (4.18–14.7)

< 0.001

• C1 vs. C0

2.71 (1.44–5.11)

0.002

2.4 (1.31–4.37)

0.004

• C2 vs. C0

5.68 (2.58–12.5)

< 0.001

5.18 (2.47–10.8)

< 0.001

Decreased serum C3 (vs. no decreased)

2.85 (1.32–6.14)

0.007

2.13 (1.02–4.47)

0.04

Intense C3 deposition (vs. no intense)

1.72 (0.87–3.41)

0.11

1.43 (0.78–2.59)

0.24

IgA co-deposition (vs. IgA alone)

-

-

-

-

• IgG + IgA

1.01 (0.36–2.83)

0.97

0.68 (0.28–1.62)

0.38

• IgM + IgA

2.01 (0.76–5.33)

0.15

1.49 (0.67–3.31)

3.31

LM pattern (vs. mesangioproliferative)

-

-

-

-

• Proliferative/necrotizing

2.91 (1.32–6.42)

0.008

1.96 (0.97–3.97)

0.06

• Crescentic

6.38 (1.99–20.4)

0.002

5.31 (1.92–14.6)

0.001

• Sclerosing

5.74 (2.72–12.1)

< 0.001

4.4 (2.32–8.34)

< 0.001

Multivariate analysis

A) Light microscopy model 1

eGFR (for 1 ml/min/1.73m2)

0.92 (0.89–0.94)

< 0.001

0.93 (0.92–0.95)

< 0.001

Proteinuria (for 1 g/day)

1.04 (0.92–1.17)

0.53

1.04 (0.92–1.16)

0.48

LM pattern (vs. mesangioproliferative)

-

-

-

-

• Proliferative/necrotizing

1.08 (0.43–2.73)

0.85

0.83 (0.36–1.91)

0.65

• Crescentic

3.77 (0.98–14.5)

0.05

3.64 (1.07–12.3)

0.03

• Sclerosing

2.7 (1.26–5.79)

0.01

2.17 (1.13–4.19)

0.02

B) Light microscopy model 2

eGFR (for 1 ml/min/1.73m2)

0.92 (0.9–0.95)

< 0.001

0.94 (0.92–0.96)

< 0.001

Proteinuria (for 1 g/day)

1.03 (0.91–1.18)

0.61

1.03 (0.92–1.16)

0.56

Oxford Classification

-

-

-

-

• M1 vs. M0

0.77 (0.32–1.83)

0.56

0.81 (0.37–1.73)

0.58

• E1 vs. E0

0.85 (0.39–1.82)

0.68

0.79 (0.38–1.6)

0.51

• S1 vs. S0

0.81 (0.42–1.53)

0.51

0.95 (0.53–1.7)

0.88

• T1 vs. T0

1.33 (0.56–3.13)

0.51

1.57 (0.73–3.35)

0.24

• T2 vs. T0

1.84 (0.82–4.11)

0.13

2.13 (1.01–4.47)

0.04

• C1 vs. C0

1.08 (0.46–2.51)

0.85

1.04 (0.48–2.24)

0.91

• C2 vs. C0

2.61 (0.87–7.82)

0.08

3.17 (1.16–8.7)

0.02

C) Immunofluorescence model

eGFR (for 1 ml/min/1.73m2)

0.9 (0.86–0.94)

< 0.001

0.92 (0.89–0.95)

< 0.001

Proteinuria (for 1 g/day)

1.31 (1.1–1.55)

0.002

1.26 (1.1–1.24)

0.001

Decreased serum C3 (vs. no decreased)

8.05 (2.7-24.04)

< 0.001

4.83 (1.85–12.6)

0.001

Intense C3 deposition (vs. no intense)

3.33 (1.21–9.2)

0.02

2.28 (1.008–5.18)

0.04

IgA co-deposition (vs. IgA alone)

-

-

-

-

• IgG + IgA

1.02 (0.27–3.91)

0.96

0.74 (0.24–2.19)

0.58

• IgM + IgA

1.03 (0.31–3.44)

0.95

0.97 (0.38–2.49)

0.96