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  2. The objective of this article is to describe the organisation of an international, clinical registry, the Chronic Kidney Disease Observational Database (CKDOD), the processes of enrolling patients and entering...

    Authors: Bharat Shah, Ashok Kirpalani, Sham Sunder, Ashwani Gupta, Umesh Khanna, Deodatta Chafekar, Li Ping Tan, Dhavee Sirivongs, Dilip Pahari, Gokul Nath and Talat Alp Ikizler
    Citation: BMC Nephrology 2015 16:215
    Content type: Study protocol Published on:

  3. Some nephrologists have advocated an individualized approach to the prescription of bicarbonate hemodialysis. However, the utility of monthly serum bicarbonate levels for guiding and evaluating such treatment ...

    Authors: Ravi Patel, William Paredes, Charles B. Hall, Mark A. Nader, Deepak Sapkota, Vaughn W. Folkert and Matthew K. Abramowitz
    Citation: BMC Nephrology 2015 16:214
    Content type: Research article Published on:

  4. Reports on the histopathology of childhood nephrotic syndrome (NS) had emanated from our Centre since the 1960s and by the late 1980s and early 1990s, a change was observed and reported. Taking into considerat...

    Authors: Adanze O. Asinobi, Adebowale D. Ademola, Clement A. Okolo and Joseph O. Yaria
    Citation: BMC Nephrology 2015 16:213
    Content type: Research article Published on:

  5. Pyrrolidine dithiocarbamate (PDTC) reduces renal cyst growth in a rodent model of polycystic kidney disease (PKD) but the mechanism of action is not clear. Here, we investigated the hypothesis that PDTC reduce...

    Authors: Michelle H. T. Ta, David Liuwantara and Gopala K. Rangan
    Citation: BMC Nephrology 2015 16:212
    Content type: Research article Published on:

  6. Few studies have focused on investigating hypoalbuminemia in patients during earlier stages of chronic kidney disease (CKD). In particular, little is known about the role of gastrointestinal (GI) symptoms. Our...

    Authors: Xuehan Zhang, Nisha Bansal, Alan S. Go and Chi-yuan Hsu
    Citation: BMC Nephrology 2015 16:211
    Content type: Research article Published on:

  7. The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. Th...

    Authors: Hilde M. Storhaug, Ingrid Toft, Jon Viljar Norvik, Trond Jenssen, Bjørn O. Eriksen, Toralf Melsom, Maja-Lisa Løchen and Marit Dahl Solbu
    Citation: BMC Nephrology 2015 16:210
    Content type: Research article Published on:

  8. Percutaneous renal biopsy (PRB) is an important diagnostic procedure. Despite advances in its safety profile there remains a small but significant risk of bleeding complications. Traditionally, operators train...

    Authors: Scott W. Oliver, Rajan K. Patel, Khalid A. Ali, Colin C. Geddes and Bruce MacKinnon
    Citation: BMC Nephrology 2015 16:209
    Content type: Technical advance Published on:

  10. Atypical hemolytic uremic syndrome (aHUS) is a rare, genetically-mediated systemic disease most often caused by chronic, uncontrolled complement activation that leads to systemic thrombotic microangiopathy (TM...

    Authors: Christoph Licht, Gianluigi Ardissino, Gema Ariceta, David Cohen, J. Alexander Cole, Christoph Gasteyger, Larry A. Greenbaum, Sally Johnson, Masayo Ogawa, Franz Schaefer, Johan Vande Walle and Véronique Frémeaux-Bacchi
    Citation: BMC Nephrology 2015 16:207
    Content type: Research article Published on:

  11. Acute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier...

    Authors: Sahra Pajenda, Aysegül Ilhan-Mutlu, Matthias Preusser, Sebastian Roka, Wilfred Druml and Ludwig Wagner
    Citation: BMC Nephrology 2015 16:206
    Content type: Research article Published on:

  12. Removal of phosphate by peritoneal dialysis is insufficient to maintain normal serum phosphate levels such that most patients must take phosphate binders with their meals. However, phosphate ‘counting’ is comp...

    Authors: Simon Leung, Brendan McCormick, Jessica Wagner, Mohan Biyani, Susan Lavoie, Rameez Imtiaz and Deborah Zimmerman
    Citation: BMC Nephrology 2015 16:205
    Content type: Research article Published on:

  13. Maintaining tight glycemic control is important for prevention of diabetes-related outcomes in end-stage renal disease patients with diabetes, especially in light of their poor prognosis. This study aimed to d...

    Authors: Jinnie J. Rhee, Victoria Y. Ding, David H. Rehkopf, Cristina M. Arce and Wolfgang C. Winkelmayer
    Citation: BMC Nephrology 2015 16:204
    Content type: Research article Published on:

  14. Use of serum creatinine to estimate GFR may lead to underestimation of the association between self-reported frailty and kidney function. Our objectives were to evaluate the association of measured GFR (mGFR) ...

    Authors: Cynthia Delgado, Barbara A. Grimes, David V. Glidden, Michael Shlipak, Mark J. Sarnak and Kirsten L. Johansen
    Citation: BMC Nephrology 2015 16:203
    Content type: Research article Published on:

  15. Acceptance of disability (AOD) is a useful construct that assesses the ability of a patient to psychologically cope with chronic diseases, but its effect on long-term outcomes of patients with chronic kidney d...

    Authors: Hsin-Hung Chiang, Hanoch Livneh, How-Ran Guo, Mei-Ling Yen and Tzung-Yi Tsai
    Citation: BMC Nephrology 2015 16:202
    Content type: Research article Published on:

  16. Rituximab is widely used in kidney transplantation. However, it is not clear whether the conventional doses of maintenance immunosuppressant in rituximab-treated kidney transplantation (KT) are appropriate. In...

    Authors: Chung Hee Baek, Hyosang Kim, Hoon Yu, Eunhye Shin, Hyungjin Cho, Won Seok Yang, Duck Jong Han and Su-Kil Park
    Citation: BMC Nephrology 2015 16:201
    Content type: Research article Published on:

  17. Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome among adults. Considering the natural course of IMN, when to treat and with which immunosuppressive treatment need to be carefully...

    Authors: Shanshan Liu, Xiayu Li, Heng Li, Qian Liang, Jun Chen and Jianghua Chen
    Citation: BMC Nephrology 2015 16:200
    Content type: Research article Published on:

  18. The database of a major regional health insurer was employed to identify the number and frequency of covered patients with chronic kidney disease (CKD). We then examined the characteristics of their care as de...

    Authors: Pradeep Arora, Peter L. Elkin, Joseph Eberle, J. James Bono, Laura Argauer, Brian M. Murray, Raghu Ram and Rocco C. Venuto
    Citation: BMC Nephrology 2015 16:199
    Content type: Research article Published on:

  19. Our hypothesis was that both the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations would underestimate directly measured GFR (mGFR) to a sim...

    Authors: Richard J. MacIsaac, Elif I. Ekinci, Erosha Premaratne, Zhong X. Lu, Jas-mine Seah, Yue Li, Ray Boston, Glenn M. Ward and George Jerums
    Citation: BMC Nephrology 2015 16:198
    Content type: Research article Published on:

  21. Accurate measurement of renal function in cirrhotic patients is still challenging. To find the best test for the determination of the true glomerular filtration rate (GFR) in cirrhotic patients this study pros...

    Authors: Elisabeth Krones, Peter Fickert, Sabine Zitta, Stefan Neunherz, Katharina Artinger, Gilbert Reibnegger, Franziska Durchschein, Doris Wagner, Tatjana Stojakovic, Vanessa Stadlbauer, Günter Fauler, Rudolf Stauber, Gernot Zollner, Daniela Kniepeiss and Alexander R. Rosenkranz
    Citation: BMC Nephrology 2015 16:196
    Content type: Research article Published on:

  22. HIV infection is associated with increased risk of renal dysfunction, including tubular dysfunction (TD) related to antiretroviral therapy (ART). Tenofovir disoproxil fumarate (TDF) is becoming available for A...

    Authors: David R. Chadwick, Fred S. Sarfo, Elaine S. M. Kirk, Dorcas Owusu, George Bedu-Addo, Victoria Parris, Ann Lorraine Owusu and Richard Phillips
    Citation: BMC Nephrology 2015 16:195
    Content type: Research article Published on:

  23. Hyperphosphataemia is linked to cardiovascular disease and mortality in chronic kidney disease (CKD). Outcome in CKD is also affected by socioeconomic status. The objective of this study was to assess the asso...

    Authors: Marit D. Solbu, Peter C. Thomson, Sarah Macpherson, Mark D. Findlay, Kathryn K Stevens, Rajan K. Patel, Sandosh Padmanabhan, Alan G Jardine and Patrick B. Mark
    Citation: BMC Nephrology 2015 16:194
    Content type: Research article Published on:

  24. Multimorbidity is a growing concern for healthcare systems, with many countries experiencing demographic transition to older population profiles. Chronic kidney disease (CKD) is common but often considered in ...

    Authors: Simon D. S. Fraser, Paul J. Roderick, Carl R. May, Natasha McIntyre, Christopher McIntyre, Richard J. Fluck, Adam Shardlow and Maarten W. Taal
    Citation: BMC Nephrology 2015 16:193
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2020 21:543

  25. End-stage renal disease patients are characterized by low levels of physical activity, especially during leisure time. However, the recognition of variables associated with patterns of physical activity in thi...

    Authors: Clara S. C. Rosa, Denise R. Bueno, Giovana D. Souza, Luís A. Gobbo, Ismael F. Freitas Jr, Giorgos K. Sakkas and Henrique L. Monteiro
    Citation: BMC Nephrology 2015 16:192
    Content type: Research article Published on:

  26. In the US, African Americans (AAs) are four times more likely to develop end stage renal disease (ESRD) but half as likely to receive a kidney transplant as whites. Patient interest in kidney transplantation i...

    Authors: Titilayo O. Ilori, Nosayaba Enofe, Anju Oommen, Oluwaseun Odewole, Akinlolu Ojo, Laura Plantinga, Stephen Pastan, Justin B. Echouffo-Tcheugui and William McClellan
    Citation: BMC Nephrology 2015 16:191
    Content type: Research article Published on:

  27. Glomerular diseases are potentially fatal, requiring aggressive interventions and close monitoring. Urine is a readily-accessible body fluid enriched in molecular signatures from the kidney and therefore parti...

    Authors: Marie C. Hogan, John C. Lieske, Chrysta C. Lienczewski, Lisa L. Nesbitt, Larysa T. Wickman, Christina M. Heyer, Peter C. Harris, Christopher J. Ward, Jamie L. Sundsbak, Luca Manganelli, Wenjun Ju, Jeffrey B. Kopp, Peter J. Nelson, Sharon G. Adler, Heather N. Reich, Lawrence B. Holzmann…
    Citation: BMC Nephrology 2015 16:190
    Content type: Research article Published on:

  28. Medical decision-making is critical to patient survival and well-being. Patients with end stage renal disease (ESRD) are faced with incrementally complex decision-making throughout their treatment journey. The...

    Authors: Anuradha Jayanti, Markus Neuvonen, Alison Wearden, Julie Morris, Philip Foden, Paul Brenchley and Sandip Mitra
    Citation: BMC Nephrology 2015 16:189
    Content type: Research article Published on:

  29. Despite limitations of routine methods, Clinical Practice Guidelines support the assessment of bone mineral density (BMD) and vascular calcification in renal transplant recipients. Changes in fat mass also occ...

    Authors: Sinead Kinsella, Kevin Murphy, Micheal Breen, Siobhan O’Neill, Patrick McLaughlin, Joe Coyle, Conor Bogue, Fiona O’Neill, Niamh Moore, AnneMarie McGarrigle, Michael G. Molloy, Michael M. Maher and Joseph A. Eustace
    Citation: BMC Nephrology 2015 16:188
    Content type: Research article Published on:

  30. Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease, characterized by increased concentrations of serum IgM and the presence of circulating anti-mitochondrial antibodies. Al...

    Authors: Shintaro Yamaguchi, Tatsuya Maruyama, Shu Wakino, Hirobumi Tokuyama, Akinori Hashiguchi, Shinichiro Tada, Koichiro Homma, Toshiaki Monkawa, James Thomas, Kazutoshi Miyashita, Isao Kurihara, Tadashi Yoshida, Konosuke Konishi, Koichi Hayashi, Matsuhiko Hayashi and Hiroshi Itoh
    Citation: BMC Nephrology 2015 16:187
    Content type: Case report Published on:

  31. Patients with chronic kidney disease tend to have impaired functional status, and this can increase the risk of morbidity and mortality. However, no previous studies have rigorously evaluated the relationship ...

    Authors: Chia-Ter Chao, Hung-Bin Tsai, Chia-Yi Wu, Nin-Chieh Hsu, Yu-Feng Lin, Jin-Shing Chen and Kuan-Yu Hung
    Citation: BMC Nephrology 2015 16:186
    Content type: Research article Published on:

  32. Anti-glomerular basement membrane (GBM) antibody disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis caused by autoantibodies against the α3-chain of type IV collagen ...

    Authors: China Nagano, Yoshimitu Goto, Katuaki Kasahara and Yoshiyuki Kuroyanagi
    Citation: BMC Nephrology 2015 16:185
    Content type: Case report Published on:

  33. A representative cross-sectional study showed that chronic itch (lasting for a minimum of 6 weeks) affects 25.2 % (point prevalence) of hemodialysis (HD) patients. Pathophysiology and etiology of chronic itch ...

    Authors: Elke Weisshaar, Melanie Weiss, Jutta Passlick-Deetjen, Ulrich Tschulena, Klaudia Maleki and Thomas Mettang
    Citation: BMC Nephrology 2015 16:184
    Content type: Research article Published on:

  34. Coenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity ...

    Authors: Catherine K. Yeung, Frederic T. Billings IV, Adam J. Claessens, Baback Roshanravan, Lori Linke, Mary B. Sundell, Suhail Ahmad, Baohai Shao, Danny D. Shen, T. Alp Ikizler and Jonathan Himmelfarb
    Citation: BMC Nephrology 2015 16:183
    Content type: Research article Published on:

  35. Chronic antibody-mediated rejection is a major issue that affects long-term renal allograft survival. Since follicular helper T (Tfh) cells promote the development of antigen-specific B cells in alloimmune res...

    Authors: Jian Shi, Fengbao Luo, Qianqian Shi, Xianlin Xu, Xiaozhou He and Ying Xia
    Citation: BMC Nephrology 2015 16:182
    Content type: Research article Published on:

  36. This study will assess measures of vascular health and inflammation in Aboriginal Australian adults with chronic kidney disease (CKD), and determine if intensive periodontal intervention improves cardiovascula...

    Authors: Lisa Jamieson, Michael Skilton, Louise Maple-Brown, Kostas Kapellas, Lisa Askie, Jaqui Hughes, Peter Arrow, Sajiv Cherian, David Fernandes, Basant Pawar, Alex Brown, John Boffa, Wendy Hoy, David Harris, Nicole Mueller and Alan Cass
    Citation: BMC Nephrology 2015 16:181
    Content type: Study protocol Published on:

  37. Acute kidney injury due to glomerular bleeding has been described with IgA nephropathy and supratherapeutic warfarin anticoagulation. There is usually demonstrable tubular obstruction by erythrocyte casts asso...

    Authors: Andy K. H. Lim, Susan Brown, Ian Simpson and John P. Dowling
    Citation: BMC Nephrology 2015 16:180
    Content type: Case report Published on:

  38. Whether the choice of dialysis modality in patients with end stage renal disease may impact mortality is undecided. No randomized controlled trial has properly addressed this issue. Propensity-matched observat...

    Authors: Bård Waldum-Grevbo, Torbjørn Leivestad, Anna V Reisæter and Ingrid Os
    Citation: BMC Nephrology 2015 16:179
    Content type: Research article Published on:

  39. Novel putative mediators of acute kidney injury (AKI) include immune-cell derived tumour necrosis factor-like weak inducer of apoptosis (TWEAK), angiopoietin-2 (Ang-2) and protein pentraxin-3 (PTX3). The effec...

    Authors: Louise Schilder, S. Azam Nurmohamed, Pieter M. ter Wee, Nanne J. Paauw, Armand RJ Girbes, Albertus Beishuizen, Robert HJ Beelen and AB Johan Groeneveld
    Citation: BMC Nephrology 2015 16:178
    Content type: Research article Published on:

  40. End stage renal disease (ESRD) is prevalent in Taiwan. Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and inflammatory bowel diseases, a...

    Authors: Ciou-Sia Dai, Chen-Chung Chu, Shin-Fan Chen, Chiao-Yin Sun, Marie Lin and Chin-Chan Lee
    Citation: BMC Nephrology 2015 16:177
    Content type: Research article Published on:

  41. The pathogenesis of falling is complex, and identification of risk factors may be essential for prevention. The relationship between renal disease and falls is unclear, and the goal of this study was to collec...

    Authors: Pablo Jesús López-Soto, Alfredo De Giorgi, Elisa Senno, Ruana Tiseo, Annamaria Ferraresi, Cinzia Canella, María Aurora Rodríguez-Borrego, Roberto Manfredini and Fabio Fabbian
    Citation: BMC Nephrology 2015 16:176
    Content type: Research article Published on:

  42. Cinacalcet is used to treat secondary hyperparathyroidism among hemodialysis patients. Large-scale epidemiologic studies describing patterns of cinacalcet use, effects on parathyroid hormone (PTH), calcium, an...

    Authors: B. Diane Reams, Paul J. Dluzniewski, Thy P. Do, Susan V. Yue, Brian D. Bradbury, Abhijit V. Kshirsagar and M. Alan Brookhart
    Citation: BMC Nephrology 2015 16:175
    Content type: Research article Published on:

  43. Creatinine clearance (CrCl) based on 24 h urine collection is an established method to determine glomerular filtration rate (GFR). However, its measurement is cumbersome and the results are frequently inaccura...

    Authors: Stefan Flury, Johannes Trachsler, Albin Schwarz and Patrice M. Ambühl
    Citation: BMC Nephrology 2015 16:174
    Content type: Research article Published on:

  44. IgG4-related disease is a novel disease entity characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Typical renal pathology is tubulointerstitial nephritis with storiform...

    Authors: Kenji Ueki, Yuta Matsukuma, Kosuke Masutani, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Shigeru Tanaka, Tamotsu Kiyoshima, Satoshi Hisano, Takanari Kitazono and Kazuhiko Tsuruya
    Citation: BMC Nephrology 2015 16:173
    Content type: Case report Published on:

  45. The prevalence of depression in people receiving haemodialysis is high with estimates varying between 20 and 40 %. There is little research on the effectiveness of antidepressants in dialysis patients with the...

    Authors: Karin Friedli, Michael Almond, Clara Day, Joseph Chilcot, Maria da Silva Gane, Andrew Davenport, Ayman Guirguis, Naomi Fineberg, Benjamin Spencer, David Wellsted and Ken Farrington
    Citation: BMC Nephrology 2015 16:172
    Content type: Study protocol Published on:

  46. Plasma levels of atrial and brain natriuretic peptides (ANP and BNP) are increased in patients with chronic kidney disease (CKD) complicated with deteriorated kidney function, but the relationship between the ...

    Authors: Noriyuki Ogawa, Hiroshi Komura, Kenji Kuwasako, Kazuo Kitamura and Johji Kato
    Citation: BMC Nephrology 2015 16:171
    Content type: Research article Published on:

  47. In sub-Saharan Africa, chronic kidney disease (CKD) is being recognized as a non-communicable disease (NCD) with high morbidity and mortality. In countries like Tanzania, people access many sources, including ...

    Authors: John W. Stanifer, Joseph Lunyera, David Boyd, Francis Karia, Venance Maro, Justin Omolo and Uptal D. Patel
    Citation: BMC Nephrology 2015 16:170
    Content type: Research article Published on:

  48. Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide family. Endoplasmic reticulum stress (ERS) has been implicated in the pathology of renal ischemia/reperfusion (IRI). In the ...

    Authors: Yanhong Wang, Jihua Tian, Xi Qiao, Xiaole Su, Yang Mi, Ruijing Zhang and Rongshan Li
    Citation: BMC Nephrology 2015 16:169
    Content type: Research article Published on:

  49. The Northern Territory of Australia has a very high incidence of treated end-stage kidney disease (ESKD), largely confined to Indigenous Australians living in remote, under-resourced areas. Surveillance of chr...

    Authors: Paul D. Lawton, Joan Cunningham, Narelle Hadlow, Yuejen Zhao and Matthew D. Jose
    Citation: BMC Nephrology 2015 16:168
    Content type: Research article Published on:

  50. Chronic kidney disease (CKD) is common and is associated with excess mortality and morbidity. Better management could slow progression of disease, prevent metabolic complications, and reduce cardiovascular out...

    Authors: Delphine S. Tuot, Alexandra Velasquez, Charles E. McCulloch, Tanushree Banerjee, Yunnuo Zhu, Chi-yuan Hsu, Margaret Handley, Dean Schillinger and Neil R. Powe
    Citation: BMC Nephrology 2015 16:166
    Content type: Study protocol Published on:
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