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  1. Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement s...

    Authors: Julia Smedbråten, Geir Mjøen, Anders Hartmann, Anders Åsberg, Halvor Rollag, Tom Eirik Mollnes, Leiv Sandvik, Morten W. Fagerland, Steffen Thiel and Solbjørg Sagedal
    Citation: BMC Nephrology 2016 17:148
    Content type: Research article Published on:

  2. Mortality in patients with end-stage renal disorders is often a consequence of cardiovascular complications. Renal replacement therapies may contribute to this morbidity by promoting cellular activation. In re...

    Authors: Gergely Becs, Renáta Hudák, Zsolt Fejes, Ildikó Beke Debreceni, Harjit Pal Bhattoa, József Balla and János Kappelmayer
    Citation: BMC Nephrology 2016 17:147
    Content type: Research article Published on:

  3. Several shared common gene networks participate in development of interstinal ganglia and also nephron formation; the glial cell line-derived neurotrophic factor/Ret/glial cell line-derived neurotrophic factor...

    Authors: Keisuke Sugimoto, Tomoki Miyazawa, Hitomi Nishi, Kohei Miyazaki, Takuji Enya, Mitsuru Okada and Tsukasa Takemura
    Citation: BMC Nephrology 2016 17:146
    Content type: Case report Published on:

  4. The current standard for induction phase treatment of lupus nephritis is steroid combined with mycophenolate mofetil or pulse intravenous cyclophosphamide (IVC). The lowest dose of IVC recommended for inductio...

    Authors: Mahesh R. Sigdel, Mukunda P. Kafle and Dibya Singh Shah
    Citation: BMC Nephrology 2016 17:145
    Content type: Research article Published on:

  5. Vitamin D (25-hydroxyvitamin D; 25[OH]D) deficiency (VDD) is highly prevalent in chronic kidney disease. The aim of this study was to evaluate the effect of oral ergocalciferol supplementation on requirement o...

    Authors: Gaurav Agarwal, Padam Hirachan, Jonathan Gelfond, Paolo Fanti, Claudia Hura and Shweta Bansal
    Citation: BMC Nephrology 2016 17:144
    Content type: Research article Published on:

  6. Cardiovascular disease (CVD) is often comorbid with chronic kidney disease (CKD). Small low-density lipoprotein cholesterol (sdLDL-C) has also been found to increase risk for CVD. The goal of the present study...

    Authors: Hao Shen, Yan Xu, Jingfen Lu, Chunfang Ma, Yadong Zhou, Qiong Li, Xu Chen, Ao Zhu and Guorong Shen
    Citation: BMC Nephrology 2016 17:143
    Content type: Research article Published on:

  7. To investigate the combined use of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) and blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) to assess rat renal function using a 1.5T...

    Authors: Neil P. Jerome, Jessica K. R. Boult, Matthew R. Orton, James d’Arcy, David J. Collins, Martin O. Leach, Dow-Mu Koh and Simon P. Robinson
    Citation: BMC Nephrology 2016 17:142
    Content type: Research article Published on:

  8. The orally administered spherical carbon adsorbent AST-120 is used on-label in Asian countries to slow renal disease progression in patients with progressive chronic kidney disease (CKD). Recently, two multina...

    Authors: Gerald Schulman, Tomas Berl, Gerald J. Beck, Giuseppe Remuzzi, Eberhard Ritz, Miho Shimizu, Yuko Shobu and Mami Kikuchi
    Citation: BMC Nephrology 2016 17:141
    Content type: Research article Published on:

  9. Immunotactoid glomerulopathy (ITG) is a rare cause of proteinuria characterized by organized microtubular deposits in the glomerulus. ITG has been associated with underlying lymphoproliferative disorders and a...

    Authors: Aditi Khandelwal, Martina A. Trinkaus, Hassan Ghaffar, Serge Jothy and Marc B. Goldstein
    Citation: BMC Nephrology 2016 17:140
    Content type: Case report Published on:

  10. Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hypergl...

    Authors: Rosa M. Montero, Gurjeet Bhangal, Charles D. Pusey, Andrew H. Frankel and Frederick W. K. Tam
    Citation: BMC Nephrology 2016 17:139
    Content type: Research article Published on:

  11. Low-protein diets (LPD) are an important means of delaying the need for dialysis and attaining a stable metabolic balance in chronic kidney disease (CKD). Many authors consider a low educational level and illi...

    Authors: Stefania Maxia, Valentina Loi, Irene Capizzi, Giorgina Barbara Piccoli, Gianfranca Cabiddu and Antonello Pani
    Citation: BMC Nephrology 2016 17:138
    Content type: Case report Published on:

  12. Tumoral calcinosis is a rare manifestation of extraskeletal calcification, featuring large calcified cystic masses in the periarticular regions of large joints. In chronic kidney disease (CKD), this disorder i...

    Authors: Fareed B. Kamar, Bikaramjit Mann and Gregory Kline
    Citation: BMC Nephrology 2016 17:137
    Content type: Case report Published on:

  13. Information on acute kidney injury (AKI) in elderly hospitalized patients is limited. This study aims to assess the incidence, risk factors and outcomes of AKI in elderly Chinese patients.

    Authors: Shuwang Ge, Sheng Nie, Zhangsuo Liu, Chunbo Chen, Yan Zha, Jing Qian, Bicheng Liu, Siyuan Teng, Anping Xu, Wei Bin, Xin Xu and Gang Xu
    Citation: BMC Nephrology 2016 17:136
    Content type: Research article Published on:

  14. Type 2 diabetes (T2DM) is the leading cause of chronic kidney disease (CKD) in western countries. The combination of both increases the risk of end stage renal disease (ESRD), cardiovascular events and all-cau...

    Authors: Jean-Michel Halimi, Dominique Joly, Christian Combe, Gabriel Choukroun, Bertrand Dussol, Jean-Pierre Fauvel, Stéphane Quéré and Béatrice Fiquet
    Citation: BMC Nephrology 2016 17:135
    Content type: Research article Published on:

  15. Little is known about the effect of multiple, or subsequent, ischemic strokes in patients receiving hemodialysis.

    Authors: James B. Wetmore, Jonathan D. Mahnken and Milind A. Phadnis
    Citation: BMC Nephrology 2016 17:134
    Content type: Research article Published on:

  16. Long-term outcomes after acute kidney injury (AKI) include incremental loss of function and progression towards chronic kidney disease (CKD); however, the pathogenesis of AKI to CKD remains largely unknown. Cl...

    Authors: Jia Guo, Qiunong Guan, Xiuheng Liu, Hao Wang, Martin E. Gleave, Christopher Y. C. Nguan and Caigan Du
    Citation: BMC Nephrology 2016 17:133
    Content type: Research article Published on:

  17. Pregnancy in women with advanced CKD becoming increasingly common. However, experience with low-protein diets in CKD patients in pregnancy is still limited.

    Authors: Rossella Attini, Filomena Leone, Silvia Parisi, Federica Fassio, Irene Capizzi, Valentina Loi, Loredana Colla, Maura Rossetti, Martina Gerbino, Stefania Maxia, Maria Grazia Alemanno, Fosca Minelli, Ettore Piccoli, Elisabetta Versino, Marilisa Biolcati, Paolo Avagnina…
    Citation: BMC Nephrology 2016 17:132
    Content type: Research article Published on:

  18. Native arteriovenous fistula (AVF) is the most appropriate type of vascular access for chronic dialysis. Its patency rates depend on vascular wall characteristics. Ketoacid analogues of essential amino acids (...

    Authors: Cristiana David, Ileana Peride, Andrei Niculae, Alexandra Maria Constantin and Ionel Alexandru Checherita
    Citation: BMC Nephrology 2016 17:131
    Content type: Research article Published on:

  19. Acute kidney injury (AKI) has been associated with high morbidity and mortality rates among critically ill children. Cystatin C is a protease inhibitor, and studies have shown that it is a promising marker for...

    Authors: Osama Y. Safdar, Mohammed Shalaby, Norah Khathlan, Bassem Elattal, Mohammed Bin Joubah, Esraa Bukahri, Mafaza Saber, Arwa Alahadal, Hala Aljariry, Safaa Gasim, Afnan Hadadi, Abdullah Alqahtani, Roaa Awleyakhan and Jameela A. Kari
    Citation: BMC Nephrology 2016 17:130
    Content type: Research article Published on:

  20. Nutrition has been an important part of medical management in patients with chronic kidney disease for more than a century. Since the 1970s, due to technological advances in renal replacement therapy (RRT) suc...

    Authors: Maria Chan
    Citation: BMC Nephrology 2016 17:129
    Content type: Correspondence Published on:

  22. Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients. Aldoste...

    Authors: Gemma Currie, Alison H. M. Taylor, Toshiro Fujita, Hiroshi Ohtsu, Morten Lindhardt, Peter Rossing, Lene Boesby, Nicola C. Edwards, Charles J. Ferro, Jonathan N. Townend, Anton H. van den Meiracker, Mohammad G. Saklayen, Sonia Oveisi, Alan G. Jardine, Christian Delles, David J. Preiss…
    Citation: BMC Nephrology 2016 17:127
    Content type: Research article Published on:

  23. Cameroon is a low–middle income country with a rich diversity of culture and cuisine. Chronic kidney disease (CKD) is common in Cameroon and over 80 % of patients present late for care, precluding the use of t...

    Authors: Gloria Enow Ashuntantang, Hermine Fouda, Francois Folefack Kaze, Marie-Patrice Halle, Crista Tabi-Arrey and Magloire Biwole-Sida
    Citation: BMC Nephrology 2016 17:126
    Content type: Correspondence Published on:

  24. Collapsing Glomerulopathy (CG), also known as the collapsing variant of Focal Segmental Glomerulosclerosis (FSGS), is distinct in both its clinical severity and its pathophysiologic characteristics from other ...

    Authors: Whitney Besse, Sherry Mansour, Karan Jatwani, Cynthia C. Nast and Ursula C. Brewster
    Citation: BMC Nephrology 2016 17:125
    Content type: Case report Published on:

  25. Dietary treatment is helpful in CKD patients, but nutritional interventions are scarcely implemented. The main concern of the renal diets is its feasibility with regards to daily clinical practice especially i...

    Authors: Adamasco Cupisti, Claudia D’Alessandro, Biagio Di Iorio, Anna Bottai, Claudia Zullo, Domenico Giannese, Massimiliano Barsotti and Maria Francesca Egidi
    Citation: BMC Nephrology 2016 17:124
    Content type: Research article Published on:

  26. Restriction of dietary sodium is routinely recommended for patients with chronic kidney disease (CKD). Whether or not sodium intake is associated with the progression of CKD and mortality remains controversial...

    Authors: Andrea Mazarova, Amber O. Molnar, Ayub Akbari, Manish M. Sood, Swapnil Hiremath, Kevin D. Burns, Timothy O. Ramsay, Ranjeeta Mallick, Gregory A. Knoll and Marcel Ruzicka
    Citation: BMC Nephrology 2016 17:123
    Content type: Research article Published on:

  27. A link between IgA nephropathy and Crohn’s disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropath...

    Authors: Tomohiro Terasaka, Haruhito A. Uchida, Ryoko Umebayashi, Keiko Tsukamoto, Keiko Tanaka, Masashi Kitagawa, Hitoshi Sugiyama, Hiroaki Tanioka and Jun Wada
    Citation: BMC Nephrology 2016 17:122
    Content type: Case report Published on:

  28. Chronic kidney disease (CKD) is a global health burden, yet it is still underrepresented within public health agendas in many countries. Studies focusing on the natural history of CKD are challenging to design...

    Authors: Thomas Dienemann, Naohiko Fujii, Paula Orlandi, Lisa Nessel, Susan L. Furth, Wendy E. Hoy, Seiichi Matsuo, Gert Mayer, Shona Methven, Franz Schaefer, Elke S. Schaeffner, Laura Solá, Bénédicte Stengel, Christoph Wanner, Luxia Zhang, Adeera Levin…
    Citation: BMC Nephrology 2016 17:121
    Content type: Research article Published on:

  29. Hemodiafiltration with on-line endogenous reinfusion (HFR) is an extracorporeal dialytic method that combines diffusion, convection and adsorption. HFR-Supra (HFR-S) is a second-generation system with increase...

    Authors: Simonetta Palleschi, Paolo M. Ghezzi, Giuseppe Palladino, Barbara Rossi, Marino Ganadu, Domenica Casu, Maria Cossu, Giovanni Mattana, Antonio Maria Pinna, Bruno Contu, Tonina Ghisu, Alessandro Monni, Luana Gazzanelli, Maria Cristina Mereu, Franco Logias, Mario Passaghe…
    Citation: BMC Nephrology 2016 17:120
    Content type: Research article Published on:

  30. Citrate, the currently preferred anticoagulant for continuous veno-venous hemofiltration (CVVH), may influence acid-base equilibrium.

    Authors: Rita Jacobs, Patrick M. Honore, Marc Diltoer and Herbert D. Spapen
    Citation: BMC Nephrology 2016 17:119
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2020 21:105

  31. Despite the growing incidence of acute kidney injury (AKI) worldwide, there is little data on the burden and outcomes of AKI in intensive care unit (ICU) in low resource settings. The present study assessed th...

    Authors: Angèle Masewu, Jean-Robert Makulo, François Lepira, Eric Bibonge Amisi, Ernest Kiswaya Sumaili, Justine Bukabau, Vieux Mokoli, Augustin Longo, Yannick Nlandu, Yannick Engole, Cedric Ilunga, Alphonse Mosolo, Alex Ngalala, Justin Kazadi, Richard Mvuala, Jackson Athombo…
    Citation: BMC Nephrology 2016 17:118
    Content type: Research article Published on:

  32. Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and ...

    Authors: Jin-Bor Chen, Ben-Chung Cheng, Cheng-Hong Yang and Moi-Sin Hua
    Citation: BMC Nephrology 2016 17:117
    Content type: Research article Published on:

  33. Neurotoxicity is a common side effect of treatment with calcineurin inhibitors. Tremors are frequently reported as the most common manifestation. Variable presentations can include headaches, seizures, visual ...

    Authors: Ashwani K. Gupta and Nader Bahri
    Citation: BMC Nephrology 2016 17:116
    Content type: Case report Published on:

  34. This study was performed to evaluate the clinical effectiveness of alternative strategies for the prevention and treatment of patients with chronic kidney disease undergoing peritoneal dialysis and colonized by S...

    Authors: Cibele Grothe, Mônica Taminato, Angélica Belasco, Ricardo Sesso and Dulce Barbosa
    Citation: BMC Nephrology 2016 17:115
    Content type: Research article Published on:

  35. The regulation of fibroblast growth factor-23 (FGF23) secretion in patients with chronic kidney disease (CKD) is incompletely understood. An in vitro study showed that metabolic acidosis increased FGF23 in mouse ...

    Authors: Wei Chen, Michal L. Melamed, Thomas H. Hostetter, Carolyn Bauer, Amanda C. Raff, Anthony L. Almudevar, Amy Lalonde, Susan Messing and Matthew K. Abramowitz
    Citation: BMC Nephrology 2016 17:114
    Content type: Research article Published on:

  36. Chronic kidney disease (CKD) and end-stage-kidney disease (ESKD) continue to be under-diagnosed and a major burden for Aboriginal communities in central Australia. The aim of this study was to examine the risk...

    Authors: Rebecca Ritte, Joanne Luke, Craig Nelson, Alex Brown, Kerin O’Dea, Alicia Jenkins, James D. Best, Robyn McDermott, Mark Daniel and Kevin Rowley
    Citation: BMC Nephrology 2016 17:113
    Content type: Research article Published on:

  37. Acute interstitial nephritis secondary to proton pump inhibitors (PPIs) frequently goes undiagnosed due to its subacute clinical presentation, which may later present as chronic kidney disease (CKD). We invest...

    Authors: Pradeep Arora, Anu Gupta, Mojgan Golzy, Nilang Patel, Randolph L. Carter, Kabir Jalal and James W. Lohr
    Citation: BMC Nephrology 2016 17:112
    Content type: Research article Published on:

  38. As a result of difficulties related to their illness, diagnosis and treatment, patients with end-stage renal disease experience significant emotional and psychological problems, which untreated can have consid...

    Authors: Francesca Taylor, Celia Taylor, Jyoti Baharani, Johann Nicholas and Gill Combes
    Citation: BMC Nephrology 2016 17:111
    Content type: Study protocol Published on:

  39. Transcription factor Nrf2 protects from experimental acute kidney injury (AKI) and is promising to limit progression in human chronic kidney disease (CKD) by upregulating multiple antioxidant genes. We recentl...

    Authors: Sanjeev Noel, Lois J. Arend, Samatha Bandapalle, Sekhar P. Reddy and Hamid Rabb
    Citation: BMC Nephrology 2016 17:110
    Content type: Research article Published on:

  40. Fluid overload is frequently found in acute kidney injury patients in critical care units. Recent studies have shown the relationship of fluid overload with adverse outcomes; hence, manage and optimization of ...

    Authors: Rolando Claure-Del Granado and Ravindra L. Mehta
    Citation: BMC Nephrology 2016 17:109
    Content type: Debate Published on:

  41. Kidney transplantation (KTx) disparity is a significant problem in the United States, particularly in the Southeastern region. In response to this phenomenon, the Southeastern Kidney Transplant Coalition was c...

    Authors: Teri Browne, Ahinee Amamoo, Rachel E. Patzer, Jenna Krisher, Henry Well, Jennifer Gander and Stephen O. Pastan
    Citation: BMC Nephrology 2016 17:108
    Content type: Research article Published on:

  42. Increasing the weekly frequency of hemodialysis sessions has positive effects, on the control of several biological data of patients. However, knowledge about Daily HemoDialysis (DHD) practices is limited in F...

    Authors: Adélaïde Pladys, Sahar Bayat, Anne Kolko, Clémence Béchade, Cécile Couchoud and Cécile Vigneau
    Citation: BMC Nephrology 2016 17:107
    Content type: Research article Published on:

  43. New-onset diabetes mellitus after transplantation (NODAT) is a serious complication following renal transplantation. The aim of this study was to identify the risk factors for the development of NODAT in Korea...

    Authors: Hoon Yu, Hyosang Kim, Chung Hee Baek, Seung Don Baek, Soomin Jeung, Duck Jong Han and Su-Kil Park
    Citation: BMC Nephrology 2016 17:106
    Content type: Research article Published on:

  44. Chronic kidney disease (CKD) is an emerging health public problem in Brazil. Nutritional counseling with focus on protein restriction is a promising strategy to treatment of nondialysis CKD patients due its ef...

    Authors: Denise Mafra and Viviane O. Leal
    Citation: BMC Nephrology 2016 17:105
    Content type: Correspondence Published on:

  45. Evidence on the role of plasma exchange for treating recurrent post-transplant focal segmental glomerulosclerosis (FSGS) comes largely from individual cases and uncontrolled series. We conducted a systematic r...

    Authors: Abdullah Kashgary, Jessica M. Sontrop, Lihua Li, Ahmed A. Al-Jaishi, Zainab N. Habibullah, Roaa Alsolaimani and William F. Clark
    Citation: BMC Nephrology 2016 17:104
    Content type: Research article Published on:

  46. Predialysis nephrology care is associated with lower mortality and rates of hospitalization following chronic dialysis initiation. Whether more frequent predialysis nephrology care is associated with other fav...

    Authors: Michael J. Fischer, Kevin T. Stroupe, James S. Kaufman, Ann M. O’Hare, Margaret M. Browning, Min-Woong Sohn, Zhiping Huo and Denise M. Hynes
    Citation: BMC Nephrology 2016 17:103
    Content type: Research article Published on:

  47. Evidence exists that nutritional therapy induces favorable metabolic changes, prevents signs and symptoms of renal insufficiency, and is able to delay the need of dialysis. Currently, the main concern of the r...

    Authors: Claudia D’Alessandro, Giorgina Barbara Piccoli, Patrizia Calella, Giuliano Brunori, Franca Pasticci, Maria Francesca Egidi, Irene Capizzi, Vincenzo Bellizzi and Adamasco Cupisti
    Citation: BMC Nephrology 2016 17:102
    Content type: Correspondence Published on:

  48. The clinic-pathological features and outcomes of Chinese patients with antineutrophil cytoplasmic autoantibody (ANCA)-positive eosinophilic granulomatosis with polyangiitis (EGPA) and renal involvement have no...

    Authors: Yinghua Chen, Yuemei Ding, Zhengzhao Liu, Haitao Zhang, Zhihong Liu and Weixin Hu
    Citation: BMC Nephrology 2016 17:101
    Content type: Research article Published on:

  50. The aims of this study are to find the prevalence of potential drug-drug interactions (DDIs) in patients with Hemodialysis and identify factors associated with these interactions if present.

    Authors: Rowa’ Al-Ramahi, Afnan R. Raddad, Alaa O. Rashed, Amneh Bsharat, Dania Abu-Ghazaleh, Eman Yasin and Oraina Shehab
    Citation: BMC Nephrology 2016 17:96
    Content type: Research article Published on:
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